Evolution engineering
Evolutionary engineering, also known as adaptive laboratory evolution (ALE), is commonly used in biological research to acquire new and desirable traits in microbes and enzymes. The desired traits include improving microbial tolerance to unfavorable environmental conditions, better and efficient use of various substrates, improvement of product yield, and even better enzymes, all of which are critically important for development of efficient microbial cell factories. Although the rational-design-based synthetic biology and metabolic engineering are mutually complementary to each other, the evolutionary engineering is convenient to use as a useful tool to overcome the overwhelmingly complexity of biological systems and fast development of industrial strains. Equipment for ALE has undergone a continuous enhancement for a more controllable experimental design and longer operation. Further, integration of automated evolutionary engineering to metabolic engineering and synthetic biology emerged as promising synthetic-evolution strategy.
Adaptive evolution strategies
"Short video"
General layers of the equipment design
All on single Arduino mega chip
Arduino basic code structure
Customized Bottle design
